The 12 Masters of Origin Cave are Non-Player Characters that have deep ties to the long history of Origin and the wider universe at large. They serve the original purpose of the caves, as a nest of creation for Rrevalk's soldiers, and have been doing so since the nest opened. However, their efforts were interrupted some thousands of years ago, during the time of The Rebellion, which led to the deaths of both Enki and half of Totum, the subsequent hibernation of the other Masters, as well as the escape of Tamulus and Jupiter to the surface of Let. Since The Great Awakening, the remaining Masters have reawakened, and some have returned to their work.

The Masters work (or once worked) in the following pairs:

• Astraea and Tenzin
• Dawa and Raheerah
• Artio and Farina
• Nemean and Aquarian (defunct)
• Jupiter and Totum (defunct)
• Enki and Tamulus (defunct)

Since Jupiter's death, the Overseer Vargas has been promoted to Master in her place and works with Totum.